The Reaction of o-Phenylenediamine with Phenyl Phosphorodichloridate. Synthesis and Reactions of 2-Phenoxy-1,3-dihydro-2H-1,3,2-benzodiazaphosphole-2-oxide and Related Compounds

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概要

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• The reaction of o-phenylenediamine with phenylphosphorodichloridate was reexamined. Unlike Autenrieth and Bolli's report, 2-phenoxy-1,3-dihydro-2H-1,3,2-ben-zodiazaphosphole 2-oxide (I) has not been obtained by their procedure. Instead, phenylhydrogen N-(2-aminophenyl) phosphoroamidate (V) was obtained by the reaction in refluxing benzene. When the reaction was carried out by the fusion method, a roughly equal amount of V and o-phenylenediamine salt of diphenyl phosphate (VI) were isolated. The solubility and reactivity of both compounds V and VI were compared with those of the Autenrieth and Bolli's compound and it was concluded that their synthesis should be refuted. Finally the diazaphosphole I was synthesized by the reaction in bromobenzene and the properties of I was quite different from those of the Auterieth and Bolli's compound.

• 公益社団法人日本薬学会の論文
• 1973-01-25

著者

• 小泉 徹

  富山医科薬科大学薬学部薬化学

• 小泉 徹

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Koizumi T

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 新井 良侑

  Faculty of Pharmaceutical Sciences, University of Toyama

• 新井 良侑

  Faculty Of Pharmaceutical Sciences University Of Toyama

• Koizumi Toru

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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