Studies on the Synthesis of Cardiotonic Steroids. III. New and Effective Route to Bufadienolides

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概要

• 論文の詳細を見る

• An efficient synthetic method of bufa-20,22-dienolides from 20-ketopregnanes has been developed. The method involves the following reaction sequence : (1) 21-methoxy-methylenation, (2) 2-methoxydihydropyrane formation by reaction with excess dimethylsulfonium methylid, (3) transformation to buf-20 (22)-enolide structure, (4) dehydrogenation to bufa-20,22-dienolide. Application of this attractive device to readily available 3β-acetoxy-5β-pregn-14-en-20-one established a new route to resibufogenin and bufalin.

• 社団法人日本薬学会の論文
• 1977-09-25

著者

• 小泉 徹

  富山医科薬科大学薬学部薬化学

• 小泉 徹

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Koizumi T

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 織部 多喜子

  Faculty of Pharmaceutical Sciences, University of Toyama

• 林 市裕

  Faculty of Pharmaceutical Sciences, University of Toyama

• 津村 久美子

  Faculty of Pharmaceutical Sciences, University of Toyama

• 津村 久美子

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 吉井 英一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  富山医科薬科大学薬学部

• Koizumi Toru

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 林 市裕

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 織部 多喜子

  Faculty Of Pharmaceutical Sciences University Of Toyama

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