Studies on the Synthesis of Cardiotonic Steroids. I. Efficient Synthesis of Cardenolides

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概要

• 論文の詳細を見る

• Practical synthetic methods of natural cardenolides are illustrated in the syntheses of xysmalogenin and digitoxigenin. The new routes employ pregn-14-en-20-one as key intermediate which was prepared by partial reduction of 14,16-dien-20-one with triphenylstannane or triethylsilane. A general and efficient method was devised for obtaining cardenolides consisting of (1) 21-methylsulfenylation of pregnen-20-one, (2) the reaction of the resulting 21-methylthio derivative with bromoacetate and zinc, (3) alumina chromatography of epoxy ester obtained from the S-methylated Reformatsky product.

• 社団法人日本薬学会の論文
• 1975-11-25

著者

• 小泉 徹

  富山医科薬科大学薬学部薬化学

• 小泉 徹

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Koizumi T

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 林 市裕

  Faculty of Pharmaceutical Sciences, University of Toyama

• 池島 弘和

  Faculty of Pharmaceutical Sciences, University of Toyama

• 尾崎 久一

  Faculty of Pharmaceutical Sciences, University of Toyama

• 吉井 英一

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 吉井 英一

  富山医科薬科大学薬学部

• Koizumi Toru

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 林 市裕

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 尾崎 久一

  Faculty Of Pharmaceutical Sciences University Of Toyama

• 池島 弘和

  Faculty Of Pharmaceutical Sciences University Of Toyama

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