STEREOCONTROL IN INTERMOLECULAR NUCLEOPHILIC ADDITION TO N-ACYLIMINIUM ION DIRECTED BY A BICYCLO[2.2.1]HEPTENE OR 7-OXABICYCLO[2.2.1]HEPTENE GROUP. A NOVEL ROUTE TO 5-SUBSTITUTED 3-PYRROLIN-2-ONES OF HIGH OPTICAL PURITY

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概要

• 論文の詳細を見る

• Intermolecular nucleophilic additions to the conformationally rigid, tricyclic pyrrolidinium ion (derived from 2 or 6) took place exclusively from the less-hindered face fused with its bicyclo[2.2.1]heptene or 7-oxabicyclo[2.2.1]heptene moiety. Retro-Diels-Alder fragmentation of the resulting chiral 7-oxabicyclo[2.2.1]heptene system furnished a 5-substituted 3-pyrrolin-2-one without a loss of optical purity.

• 社団法人日本薬学会の論文
• 1992-06-25

著者

• 小泉 徹

  富山医科薬科大学薬学部薬化学

• 小泉 徹

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Koizumi T

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 荒井 謙次

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 藤井 昭仁

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 大野 俊之

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 小泉 徹

  Department Of Synthetic Organic Chemistry:faculty Of Pharmaceutical Sciences Toyama Medical And Phar

• 大野 俊之

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 藤井 昭仁

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• Koizumi Toru

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 荒井 謙次

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

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