Heteroaromatic Analogs of Benzomorphan. II. Synthesis of 2-Azabicyclo-[3.3.1] nonane Derivatives fused to Pyridine Ring. (2)
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概要
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1,2,3,4,5,6-Hexahydro-1,5-methanopyrido [3,2-c] azocine and 1,2,3,4,5,6-hexahydro-2,6-methanopyrido [2,3-d] azocine derivatives were synthesized by condensation reactions of acyl derivatives of 2-azabicyclo [3.3.1] nonan-7-one (XIa) with β-aminoacrolein. The key compound (XIa) was obtained by lithium aluminum hydride reduction and the subsequent acid hydrolysis of 3-methoxy-5-oxo-3-cyclohexene-1-acetamide (IXa), which was prepared starting from 3,5-dihydroxyphenylacetic acid (IV). Mass spectra of the above pyridine derivatives were briefly described, too.
- 公益社団法人日本薬学会の論文
- 1976-01-25
著者
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野村 敬一
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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野村 敬一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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安立 準
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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三橋 監物
Faculty of Pharmaceutical Sciences, University of Toyama
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三橋 監物
Faculty Of Pharmaceutical Sciences Josai University
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