Tetrahydronaphthylamines and Related Compounds. III. Synthesis of 1,2,3,4-Tetrahydro-2-naphthylamine and 6-Amino-5,6,7,8-tetrahydroquinoline Derivatives
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概要
- 論文の詳細を見る
Amino substituted 1,2,3,4-tetrahydronaphthalene and 5,6,7,8-tetrahydroquinoline derivatives (1,2,3,4-tetrahydro-6-methoxy-N-methyl-2-phenyl-2-naphthylamine, 1,2,3,4-tetrahydro-6-methoxy-N, N-dimethyl-2-phenyl-2-naphthylamine, 5,6,7,8-tetrahydro-6-(methylamino)-6-phenylquinoline and 5,6,7,8-tetrahydro-6-(dimethylamino)-6-phenylquinoline) were synthesized. Thus, Michael adducts of methyl vinyl ketone and acrylonitrile to methyl 5-cyano-2-oxo-5-phenylcyclohexanecarboxylate (I) were used for formation of skeleton of naphthalene and quinoline, respectively. Quinoline derivative was also obtained by condensation of cyclohexanone derivative with 3-aminoacrolein. Amino function was derived from nitrile via Hofmann reaction of amide. Furthermore, an interesting tricyclic compound, 3,8a-ethano-3,4,4a, 8a, 5,6-hexahydro-3-phenyl-2,7 (1H, 8H)-quinolinedione, was obtained on cyclization reaction of a Michael adduct (IIa).
- 公益社団法人日本薬学会の論文
- 1974-06-25
著者
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安立 準
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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野村 敬一
Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University
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野村 敬一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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安立 準
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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三橋 監物
Faculty of Pharmaceutical Sciences, University of Toyama
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花井 道夫
Faculty of Pharmaceutical Sciences, University of Toyama
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中山(堀) 幸子
Faculty of Pharmaceutical Sciences, University of Toyama
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花井 道夫
Faculty Of Pharmaceutical Sciences University Of Toyama
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中山(堀) 幸子
Faculty Of Pharmaceutical Sciences University Of Toyama
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三橋 監物
Faculty Of Pharmaceutical Sciences Josai University
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