Synthesis of 1,2,3,4,5,6-Hexahydro-1,5-methano-2-methylpyrido [2,3-c] azocine
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概要
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Synthesis of benzomorphan analog of which aromatic ring is heterocyclic was investigated. The key compounds of this synthetic route, 2-benzoyl-2-azabicyclo [3.3.1]-nonan-8-one derivatives (X, and XII), were prepared starting from ethyl 4-pyridinepropionate (I). 1,2,3,4,5,6-Hexahydro-1,5-methanopyrido [2,3-c] azocine derivative (XV) was synthesized by condensation of XII with 3-aminoacrolein. Furthermore, the pyrazolone derivative (XI) was also prepared from X by treatment with hydrazine, and the pyrimidine derivative (XIV) was obtained from XII via the β-diketone (XIII).
- 公益社団法人日本薬学会の論文
- 1974-03-25
著者
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野村 敬一
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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安立 準
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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三橋 監物
Faculty of Pharmaceutical Sciences, University of Toyama
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白木 毅
Faculty of Pharmaceutical Sciences, University of Toyama
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白木 毅
Faculty Of Pharmaceutical Sciences University Of Toyama
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三橋 監物
Faculty Of Pharmaceutical Sciences Josai University
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