On the Cleavage of Tertiary Amines with Ethyl Chloroformate

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概要

• 論文の詳細を見る

• Forty-seven tert. amines were examined in order to observe the relative lability of the various N-substituents in respect to cleavage by ClCO_2Et in refluxing benzene. The aromatic amines did not react with ClCO_2Et, while aliphatic and alicyclic amines were cleaved to give carbamate (s) ; the tendency to cause R-N cleavage was : benzyl>allyl>methyl>ethyl>other alkyl groups. It was found that the reaction of a tert. amine with ClCO_2Et is greatly influenced by the polarity of the solvent, reaction temperature and N-substituents.

• 公益社団法人日本薬学会の論文
• 1976-02-25

著者

• 三橋 監物

  Faculty of Pharmaceutical Sciences, University of Toyama

• 米谷 正

  富山工業高等専門学校

• 塩谷 俊作

  Toyama Technical College

• 塩谷 俊作

  Toyama National College Of Technology

• 三橋 監物

  Faculty Of Pharmaceutical Sciences Josai University

関連論文

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