Studies on Structure-Activity Relationship of Analgetics. X. Syntheses of 11-Amino-2,3-benzobicyclo [3. 3. 1] nonane and 3-Phenyl-9-amino-bicyclo [3. 3. 1] nonane Derivatives.
スポンサーリンク
概要
- 論文の詳細を見る
Some derivatives of 11-amino-2,3-benzobicyclo [3. 3. 1] nonane and 3-phenyl-9-amino-bicyclo [3. 3. 1] nonane were synthesized from β-tetralon and 4-phenylcyclohexanone, respectively, through an enamine cyclization. Configuration and conformation of these bicyclic compounds were elucidated by nuclear magnetic resonance spectral analysis. A peculiar property, resembling to Sommelet reaction, of the amino group attached to bridged methylene in bicyclic system is presented. The mass spectra of the amino derivatives of bicyclo [3. 3. 1] nonane system are discussed.
- 公益社団法人日本薬学会の論文
- 1970-01-25
著者
-
三橋 監物
Faculty of Pharmaceutical Sciences, University of Toyama
-
塩谷 俊作
Toyama Technical College
-
塩谷 俊作
Toyama National College Of Technology
-
三橋 監物
Faculty Of Pharmaceutical Sciences Josai University
関連論文
- Studies on Structure-Activity Relationship of Analgetics. XIII. Syntheses of Homobenzomorphans and Related Compounds. (1)
- Heteroaromatic Analogs of Benzomorphan. III. Synthesis of 1,2,3,4,5,6-Hexahydro-2,6-methano-3-methylpyrido [3,2-d] azocine
- Heteroaromatic Analogs of Benzomorphan. II. Synthesis of 2-Azabicyclo-[3.3.1] nonane Derivatives fused to Pyridine Ring. (2)
- Tetrahydronaphthylamines and Related Compounds. III. Synthesis of 1,2,3,4-Tetrahydro-2-naphthylamine and 6-Amino-5,6,7,8-tetrahydroquinoline Derivatives
- Synthesis of 1,2,3,4,5,6-Hexahydro-1,5-methano-2-methylpyrido [2,3-c] azocine
- Thiazole Analogs of Benzomorphans. II. Synthesis of Novel Thiazolo [5,4-f] morphans
- Thiazole Analogs of Benzomorphans. I. Synthesis of Novel Thiazolo [4,5-f] morphans
- Heteroaromatic Analogs of Benzomorphan. Synthesis of Novel Thiazolo [4,5-f] morphans
- Tetrahydronaphthylamines and Related Compounds. II. Synthesis of 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-phenyl-2-naphthylamine
- Syntheses of 1,2,3,4-Tetrahydro-2-naphthylamine Derivatives
- Synthesis of 2-Hydroxyemthyl-4-phenyl-2,3,4,5,6,7-hexahydro-1H-azepine and Its Derivatives
- On the Condensation Products of Nitromalondialdehyde with Ethylenediamine
- A Conveient Preparation of 3-Phenylcyclopentanone
- Synthesis of Homobenzomorphans and the Related Compounds. III. 3-Methyl-2,3,4,5,6,7-hexahydro-1,6-methano-1H-3-benzazonine
- On the Cleavage of Tertiary Amines with Ethyl Chloroformate
- Mass Spectral Studies of Aza- and Diazabenzobicycloalkanes. II. Some Aspects of Mass Spectrometry of 1,3-Bridged 1,2,3,4-Tetrahydronaphthalenes, 2,4-Bridged 1,2,3,4-Tetrahydroisoquinolines and 1,3-Bridged 1,2,3,4-Tetrahydroquinolines
- Acetamido-azabenzobicyclo[3,3,1]nonane類の合成 : 中枢性鎮痛剤の化学構造と薬理作用の関係に関する研究(第12報)(有機化学)
- Mass Spectral Studies of Aza-and Diazabenzobicycloalkanes. I. Some Aspects of Mass Spectrometry of 1,3-Bridged 1,2,3,4-Tetrahydroisoquinolines
- Studies on Structure-Activity Relationship of Analgetics. X. Syntheses of 11-Amino-2,3-benzobicyclo [3. 3. 1] nonane and 3-Phenyl-9-amino-bicyclo [3. 3. 1] nonane Derivatives.
- Syntheses of Azabenzobicycloalkanes
- A New Example of Abnormal Cleavage of Amide Group with Lithium Aluminum Hydride
- Studies on Diazabenzobicyclo [3.3.1] nonane System. VIII. Synthesis of 8,9-Dimethoxy-11-benzoyl-1,2,5,6-tetrahydro-2,6-imino-3-benzazocin-4 (3H)-one
- Studies on Diazabenzobicyclo [3.3.1] nonane System. VII. Synthesis of 1,2,3,4,5,6-Hexahydro-1,5-methanobenzo [e][1,2] diazocine Derivatives and an Example of Abnormal Cleavage of Hydrazide by Lithium Aluminum Hydride
- 4-Acylaminoisoquinolineの接触還元について
- Studies on Diazabenzobicyclo [3.3.1] nonane System. VI. Syntheses of 1,2,3,4-Tetrahydro-6H-1,5-methanobenzo [d][1,2] diazocine Derivatives
- Studies on Diazabenzobicyclo-[3.3.1]nonane System. V. Nuclear Magnetic Resonance Spectral Studies on Diazabenzobicyclo[3.3.1]nonane System
- Studies on Diazabenzobicyclo [3.3.1] nonane System. IV. Synthesis of 1,2,3,4,5,6-Hexahydro-1,5-methanobenzo [e] [1,3] diazocine Derivatives
- Diazabenzobicyclo[3.3.1]nonane系化合物の研究(第3報) : (8-Methoxy-1,2,3,4,5,6-hexahydro-1,5-imino-3-benzazocine誘導体の合成とN→N' Acyl転位の一新例について
- Studies on Diazabenzobicyclo [3.3.1] nonane System. I. Syntheses of 3,4,5,6-Tetrahydro-2H-1,5-methanobenzo [g]-[1,4] diazocine and its Derivatives.
- A New Synthesis of 6,7-Benzomorphan
- Synthesis of 3-Carboxymethyl-I-(N-methylaminomethyl)indane and Its Ester
- On the Cleavage of Tertiary Amines with Ethyl Chloroformate
- Reaction of Alkyl Dialkoxyphosphinyl Formate with Strong Base
- Studies on Structure-Activity Relationship of Analgetics. XVII. Syntheses of Homobenzomorphans and Related Compounds.(2)
- Synthesis of 9-Amino-3,6-dimethy1-8-methoxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine
- 3-Methyl-2,3,4,5,6,7-hexahydro-2,7-methano-1H-3-benzazonine の一新合成法について
- The Reaction of α, β-Unsaturated Ketones with Azides. III.
- Thiazole Analogs of Benzomorphans. III. Syntheses of 4,5,6,7,8,9-Hexahydro-4,8-methano-5-methylthiazolo [4,5-c] azocine and 4,5,6,7,8,9-Hexahydro-4,8-methano-5-methylthiazolo [5,4-c] azocine
- Reaction of Conjugated Dienones with Hydrazoic Acid
- The Reaction of α, β-Unsaturated Cycloalkenones with Azides. I. The Anomalous Products in the Schmidt Reaction