Indoles. III. A New Synthesis of 4-Indolecarboxylic Acid
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概要
- 論文の詳細を見る
As a new and convenient method for the synthesis of 4-indolecarboxylic acid (1), the synthesis was started with the reduction of 3-nitrophthalimide (4) with sodium borohydride, followed by hydrolysis of the product to obtain 3-hydroxy-4-nitrophthalide (6). Treatment of 6 with 2 moles of diazomethane gave 2-methoxycarbonyl-6-nitrostyrene oxide (7) whose reductive cyclization afforded methyl 4-indolecarboxylate (2) and it was saponified to the desired 1.
- 社団法人日本薬学会の論文
- 1972-10-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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浜口 文子
東京薬科大学
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渡辺 徳弘
Tokyo College of Pharmacy
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浜口 文子
Tokyo College of Pharmacy
-
大木 貞雄
東京薬科大学
-
渡辺 徳弘
東京薬科大学薬学部
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