Anticholinergic Agents. Synthesis of 1,1,4-Trimethyl- and 1,1,5-Trimethyl-3-diphenylmethylenepyrrolidinium Halides

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概要

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• In connection with 1,1-diethyl-2-methyl-3-diphenylmethylenepyrrolidinium bromide (1) (anticholinergic agent), 1,1,4-trimethyl-(2) and 1,1,5-trimethyl-3-diphenylmethylene-pyrrolidinium iodide (3) were synthesized. In the pharmacological examination of anticholinergic activity, the relative potencies of 2 and 3 were 0.01 and 0.27 respectively, in contrast to atropine which was defined as 1.00.

• 公益社団法人日本薬学会の論文
• 1976-06-25

著者

• 大木 貞雄

  Tokyo College of Pharmacy

• 松田 秀明

  Tokyo College Of Pharmacy

• 大木 貞雄

  東京薬科大学

• 尾澤 永紀

  Tokyo College of Pharmacy

• 矢部 裕一郎

  Tokyo College of Pharmacy

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