Indoles. I. Syntheses of 1-Acetyltryptophan and Its Derivatives, and Their Friedel-Crafts Reaction
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概要
- 論文の詳細を見る
1-Acetyltryptophan and its derivatives were synthesized in good yields from dltryptophan. Reduced nucleophilic activity in the indole ring by 1-acetylation was examined in the reaction of 1-acetyl derivatives with o-nitrophenylsulfenyl chloride (NPS-Cl) and the Friedel-Crafts reaction of them. In the reaction with NPS-Cl, 7,10,and 12 did not show the activity of 2-position in the indole ring, but the Friedel-Crafts reaction of 12 (chloride) afforded 15 cyclized to 2-position of the indole, different from only one example reported previously by Szmuszkovicz of the same reaction of 1-acetyl indole derivatives which cyclized to 4-position.
- 公益社団法人日本薬学会の論文
- 1971-03-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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長坂 達夫
Tokyo College of Pharmacy
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長坂 達夫
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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- Indoles. I. Syntheses of 1-Acetyltryptophan and Its Derivatives, and Their Friedel-Crafts Reaction