Synthesis of Pyrrolidine Derivatives with Anticholinergic Properties. IV. Synthesis, Stereochemistry, and Pharmacological Activity of N, N-Diethyl- and N, N-(epimeric)-Ethylmethyl-2-methyl-3-diphenylmethylenepyrrolidinium Salts
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概要
- 論文の詳細を見る
The ethobromide (IV) (Pyrodifenium bromide) and methiodide (VI) of N-ethyl-2-methyl-3-diphenylmethylenepyrrolidine (II) and the ethiodide (V) of N-methyl-2-methyl-3-diphenylmethylenepyrrolidine (I) were synthesized. Anti-acetylcholine action of IV, V, and VI was 0.5,1.95,and 0.25 times, respectively, of that of atropine. A marked difference was found in the intensity of the action of the epimeric N, N-ethylmethyl compounds, V and VI.
- 社団法人日本薬学会の論文
- 1968-02-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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浜口 文子
東京薬科大学
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浜口 文子
Tokyo College of Pharmacy
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吉野 元世
Tokyo College of Pharmacy
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