Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. I. Synthesis of 6H-Isoindolo [2,1-α] indoles by the Harley-Mason Method
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As an approach to the synthesis of mitomycin structure, 2-methoxy-10b, 11-dihydro-6H-isoindolo [2,1-α] indole (X) and 2-methoxy-6H-isoindolo [2,1-α] indole (XI) were synthesized. By the oxidative cyclization of 1-(2,5-dihydroxybenzyl) isoindoline (VII) with alkaline potassium ferricyanide, a dihydroindole compound, 2-hydroxy-10b, 11-dihydro-6H-isoindolo [2,1-α] indole (IX) was obtained as a main product beside a small amount of indole compound, 2-hydroxy-6H-isoindolo [2,1-α] indole (VIII).
- 公益社団法人日本薬学会の論文
- 1971-05-25
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