Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. II. Synthesis of 7-Nitro-2,3,9,9a-tetrahydro-1H-pyrrolo [1,2-α] indoles
スポンサーリンク
概要
- 論文の詳細を見る
In connection with synthesis of the ring system of mitomycins, 1H-pyrrolo [1,2-α] indoles (III to VI) were synthesized. Indole (XVIII) was synthesized by the reaction of aminodiester (XVII) and 2-chloro-5-nitrobenzaldehyde in one step. Dieckmann reaction of XVIII afforded pyrroloindole (III). By the carbene cyclization reaction, tosylhydrazone (XX) of aldehyde (XIX) gave the compound IV in poor yield, and tosylhydrazones (XXV and XXX) of ketones (XXIV and XXVIII) afforded the desired pyrroloindoles (V and VI) in good yield, respectively.
- 公益社団法人日本薬学会の論文
- 1971-05-25
著者
関連論文
- Studies on Optically Active Amino Acids. V. Synthesis of Optically Active α-Aminoalcohols by the Reduction of α-Amino Acid Esters with Sodium Borohydride
- Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. XII. : Synthesis and Anticholinergic Activity of 1,1-Dialkyl-3-diphenylmethylene-2,4-dimethylpyrrolidinium Halides
- Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. XI. The Lora-Tamayo Reaction of 3-Methyl-1,1-diphenyl-1,4-butanediol with Acetonitrile-Stannic Chloride Complex. Synthesis of 1,2,5-Trimethyl-3-diphenylmethylenepyrrolidines
- Indoles. III. A New Synthesis of 4-Indolecarboxylic Acid
- Synthesis of Pyrrolidine Derivatives with Anticholinergic Properties. IV. Synthesis, Stereochemistry, and Pharmacological Activity of N, N-Diethyl- and N, N-(epimeric)-Ethylmethyl-2-methyl-3-diphenylmethylenepyrrolidinium Salts
- Cyclization towards Carbon-Carbon Double Bond. III. A New Synthesis of 1-Pyrroline Derivatives and a Synthesis of 1,2-Dialkyl-3-diphenyl-methlenepyrrolidine Alkyl Halide, an Anti-acetylcholine Substance
- Synthesis of Quinolizine Derivatives. XIII. On the Relationship between Chemical Structure and Uterus Contracting Action of Quinolizidine Derivatives, and Synthesis of Some of these Derivatives.
- Anticholinergic Agents. Synthesis of 4-Diphenylmethylene-1,1,2,3-tetramethylpyrrolidinium Iodide
- Anticholinergic Agents. Synthesis of 1,1,4-Trimethyl- and 1,1,5-Trimethyl-3-diphenylmethylenepyrrolidinium Halides
- Aza-steroids.III.Synthesis of 17-Acetoxy-10-aza-androstan-7-one and Related Compounds
- Aza-steroids. II. Enamine Reaction of Androstanones. Synthesis of 17-Acetoxy-5β-androstano [4,3-c] quinolizidin-2'-one
- Hofmann Degradation of Quinolizidine (Synthesis of Quinolizine Derivatives. XXII)
- Aza-steroids. I. Synthesis of 9-Aza-steroid Ring System
- Synthesis of Quinolizine Derivatives. XX. Synthesis and Stereochemistry of Perhydrobenzo [c] quinolizine
- Reduction of Cyclic Imides. III. Reduction of 3- and 4-Substituted Phthalimides with Sodium Borohydride
- Photo-induced 1,3-Dipolar Cycloaddition Reaction of Aziridinedicarboximide
- Attempted Synthesis of 4,5-Epiminotetrahydro-1,2-oxazine
- Synthesis of 5-endo-Benzoyloxy-N-[amino (lower) alkyl] bicyclo [2. 2. 1] heptane-2,3-di-endo-carboxylic Acid Imides as Potential Antiarrhythmia Agents
- Synthesis of Quinolizine Derivatives. XVIII. Diastereoisomers of 3-(4-Chlorobenzyl) quinolizidine, and Uterus-contracting Agent, and 3-Lupinine
- Synthesis of Quinolizine Derivatives. XVI. Synthesis of 3-(Subst.-benzyl)quinolizidine
- Synthesis of Quinolizine Derivatives. IX. Synthesis of 3,3'-Polymethylenediquinolizidine
- Reaction of γ-Bromoacetoacetyl Compounds with Benzamide Oxime Derivatives : Synthesis of 4H-1,2,4-Oxadiazine Derivatives
- Cyclization of O-Acetoacetylbenzamide Oxime Derivatives
- Nitrogen-containing Heterocyclic Compounds derived from Sparteine. I. Synthesis of 5-Oxosparteine
- Reactions of Acyl-aminoquinone Tosylhydrazones. III. A Simple Synthesis of 7-Substituted Pyrrolo [1,2-α]-indoloquinones and Related Compounds
- Reactions of Acyl-aminoquinone Tosylhydrazones. I. A New Synthesis of Pyrrolo [1,2-α] indoloquinones and Related Compounds
- Reactions of Acyl-aminoquinone Tosylhydrazones. II. A Simple Synthesis of 5-Substituted Indazoloquinones
- Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. III. Synthesis of 2,3-Dihydro-7-hydroxy-6,9-dimethyl-5,8-dioxo-1H-pyrrolo [1,2-α] indole
- Indoles. V. Syntheses and Reactions of Cycloalkanon-[c, d] indole Derivatives
- Indoles. II. Oxidation of N-Phthaloyl-1-acetyltryptophan with Chromium Trioxide
- Studies on Benzimidazoles and Related Compounds. V. Reaction of 2-Azido-1-methylbenzimidazole with Unsaturated Compounds
- Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. II. Synthesis of 7-Nitro-2,3,9,9a-tetrahydro-1H-pyrrolo [1,2-α] indoles
- Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. I. Synthesis of 6H-Isoindolo [2,1-α] indoles by the Harley-Mason Method
- Studies on Benzimidazoles and Related Compounds. IV. Reactivity of 2-Azido-1-methylbenzimidazole
- Synthesis of Nitrogen-containing Heterocyclic Compounds through Nitrilium Salt. II. Reaction of Nitriles with 2-(2-Hydroxycyclohexyl) ethanol and 1-(2-Hydroxycyclohexyl) propan-2-ol in the Presence of Acid
- Synthesis of Nitrogen-containing Heterocyclic Compounds through Nitrilium Salt. I. Reaction of Nitriles with 2-(α-Hydroxymethyl, -ethyl, and -isopropyl) cyclohexanol in the Presence of Acid
- Synthesis of Pyrrolidine Derivatives with Anticholinergic Properties. III. Syntheses and Stereochemistry of 1,2,5-Trimethylpyrrolidine and 3-(Diphenylmethylene)-1,2,5-trimethylpyrrolidine
- Indoles. I. Syntheses of 1-Acetyltryptophan and Its Derivatives, and Their Friedel-Crafts Reaction