Studies on Benzimidazoles and Related Compounds. IV. Reactivity of 2-Azido-1-methylbenzimidazole
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概要
- 論文の詳細を見る
Reactions of 2-azido-1-methylbenzimidazole (I) with such reagents as aluminum chloride in toluene, thiobenzophenone, hydrogen bromide, and acetic anhydride were investigated and compared with those of phenyl azide. In reaction of I with acetic anhydride, 3-acetyl-1-methyl-2-benzimidazolinone (VI) and 6-acetoxy-2-diacetylamino-1-methylbenzimidazole (VII) were obtained and its reaction mechanism was discussed. Bromination of 2-amino-1-methylbenzimidazole (IIIa) with bromine in glacial acetic acid selectively occurred at C_6-position and this selectivity was also discussed.
- 公益社団法人日本薬学会の論文
- 1971-02-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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塩川 洋一
Tokyo College of Pharmacy
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塩川 洋一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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