Synthesis of Benzimidazoles and Its Related Compounds. Synthesis of Benzimidazoles and 7-Substituted 1 (3) H-Imidazo [4,5-f] quinolines
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概要
- 論文の詳細を見る
4 (7)- or 5 (6)-Substituted 2-methylbenzimidazole derivatives (III) were obtained by catalytic hydrogenation of the corresponding 2-chloro-2'-nitroacetanilide (II) in a good yield. Further, a mixture of 5 (6)-methoxy-2-methyl-6 (5)-nitrobenzimidazole (IVc) and its 4 (7)-nitro isomer was obtained by the reaction of 5 (6)-methoxy-2-methylbenzimidazole (IIIc) with fuming nitric acid. Similarly, nitration of 2,4 (7)-dimethylbenzimidazole (IIId) gave 2,4 (7)-dimethyl-5 (6)-nitrobenzimidazole (IVd). The title compounds were obtained by the reactions shown in Chart 1.
- 公益社団法人日本薬学会の論文
- 1969-06-25
著者
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石渡 三郎
Tokyo College of Pharmacy
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石渡 三郎
Tokyo College Of Pharmacy Kashiwagi Shinjuku-ku Tokyo
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塩川 洋一
Tokyo College of Pharmacy
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塩川 洋一
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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