Synthesis of Aminoisoquinolines and Related Compounds. X. A Modified Synthesis of dl-Cularine
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概要
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The Bischler-Napieralski reaction of the phenethylamides (VIIa and VIIb) gave respectively the 6-ethoxycarbamido-3,4-dihydroisoquinolines, formed by the cyclization at the position para to the ethoxycarbamido group, and both 3,4-dihydroisoquinolines were converted to the 6-aminoisoquinolines (Xa and Xb). Each 7,8-disubstituted isoquinolines (XIIa and XIIb), prepared by deamination reaction of Xa and Xb, were submitted to the Ullmann reaction to give respectively 6-methoxy-1-methyl-1,2,3,12,12a-pentahydrobenzoxepino [2,3,4-i, j] isoquinoline (XIII) and dl-cularine (Ia).
- 公益社団法人日本薬学会の論文
- 1970-09-25
著者
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佐藤 吉之
Tokyo College Of Pharmacy
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石渡 三郎
Tokyo College of Pharmacy
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藤井 起二
Tokyo College of Pharmacy
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宮司 進之
Tokyo College of Pharmacy
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板倉 啓壹
Tokyo College of Pharmacy
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石渡 三郎
Tokyo College Of Pharmacy Kashiwagi Shinjuku-ku Tokyo
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板倉 啓壹
Tokyo College Of Pharmacy Kashiwagi Shinjuku-ku Tokyo
関連論文
- Synthesis of Aminoisoquinolines and Related Compounds. X. A Modified Synthesis of dl-Cularine
- Synthesis of Aminoisoquinolines and Related Compounds. IX. Synthesis of dl-O-Methylcaseadine
- Syntheses of Aminoisoquinolines and Related Compounds. VIII. Total Synthesis of dl-Homolinearisine
- Studies on Benzimidazoles and Related Compounds. III. The Intramolecular Mannich Reaction of 2-Alkylaminomethylbenzimidazoles
- Syntheses of Aminoisoquinolines and Related Compounds. VII. Syntheses of O-Methylorientalinone and O-Methyliso-orientalinone
- Syntheses of Aminoisoquinolines and Related Compounds. VI. A Modified Synthesis of dl-Pronuciferine
- Syntheses of Aminoisoquinolines and Related Compounds. V. The Direction of the Mannich Reaction on the Aminotetrahydroisoquinolines to the Aminoprotoberberines
- Syntheses of Aminoisoquinoloines and Related Compounds. IV. Syntheses of Aminoprotoberberines by the Mannich Reaction
- Total Synthesis of dl-Homolinearisine
- Syntheses of Benzimidazoles and Related Compounds. II. Syntheses of 3H-Imidazo [4,5-f]-and 1H-Imidazo-[5,4-g] quinolines
- Syntheses of Aminoisoquinolines and Related Compounds. III. Influence of Substituents on the Direction of Ring-closure in the Bischler-Napieralski Reaction
- Synthesis of Aminoisoquinolines and Related Compounds. II. Syntheses of 6-Amino-1-benzylisoquinolines by the Bischler-Napieralski Reaction
- Deamination of 8-Amino-1,2,3,4-tetrahydro-6,7-dimethoxy-1-(4-methoxybenzyl)-2-methylisoquinoline
- Synthesis of Benzimidazoles and Its Related Compounds. Synthesis of Benzimidazoles and 7-Substituted 1 (3) H-Imidazo [4,5-f] quinolines
- Syntheses of 6-Amino-1-phenylisoquinolines by Bischler-Napieralski Reaction