Nitrogen-containing Heterocyclic Compounds derived from Sparteine. I. Synthesis of 5-Oxosparteine
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概要
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As the starting material for the synthesis of sparteine derivatives, 5-oxosparteine (II) was synthesized. Condensation of Δ^5-dehydrosparteine (IX) or Δ^<1(6)>-dehydrosparteinium ion (VIII) and benzaldehyde gave 5-benzylidene-Δ^<1(6)>-dehydrosparteinium ion (X) which was reduced to 5-benzylidenespartein (XI), and its oxidative cleave should have provied II but the objective was not attained. 5-Hydroximinosparteinium ion was obtained by the condensation of IX and nitrosyl chloride or VIII and ethyl nitrite, this sparteinium ion was reduced to 5-hydroximinosparteine (XIII), and its treatment with pyruvic acid gave the objective II. II has the same configuration as that of sparteine.
- 公益社団法人日本薬学会の論文
- 1966-02-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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杉本 和朗
Medical Department, Self Defence Force
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砂川 則
Medical Department, Self Defense Force
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砂川 則
Medical Department Self Defense Force
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