Synthesis of Quinolizine Derivatives. XVI. Synthesis of 3-(Subst.-benzyl)quinolizidine
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概要
- 論文の詳細を見る
Some kinds of simple quinolizidine derivatives were recently found to possess sparteine-like uterus contracting action and this time the new substance with stronger contracting action has been found. Among 3-(subst.-benzyl)-quinolizidine derivatives, 3-(4-chlorobenzyl)-quinolizidine (Ib) was found to be the strongest. Ib showed several folds of activity to sparteine sulfate both in vitro and in vivo and the toxicity was found to be about one third of it. The synthesis of Ib was carried out according to the two method (1) and (2) , the former synthetic process being found to be beneficial.
- 公益社団法人日本薬学会の論文
- 1966-07-25
著者
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大木 貞雄
Tokyo College of Pharmacy
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松尾 市郎
Junsei Pure Chemicals Co. Ltd.
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松尾 市郎
The Techmical Research and Development Institute, Japan Defence Agency, Medical Department Self Defe
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杉本 和朗
The Techmical Research and Development Institute, Japan Defence Agency, Medical Department Self Defe
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