Aza-steroids.III.Synthesis of 17-Acetoxy-10-aza-androstan-7-one and Related Compounds
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As one of the 10-aza-steroid system, 17-acetoxy-10-aza-androstan-7-one(1) was synthesized. Condensation of hexahydroindanone(16) and ethyl piperidinoacetate(3) gave a mixture of β-amino-enones with angular (17) and linear (18) structures. The separated 17 was reduced and then oxidized to 1. Reaction between 3 and testosterone (7) mainly gave amino-dienone (8) of linear structure. Such a tendency was also seen in the case of tetrahydroindanone (14) and the amino-dienone (19) of linear structure was obtained solely.
- 公益社団法人日本薬学会の論文
- 1973-01-25
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