Synthesis of 1H-Pyrrolo [1,2-α] indole Derivatives. III. Synthesis of 2,3-Dihydro-7-hydroxy-6,9-dimethyl-5,8-dioxo-1H-pyrrolo [1,2-α] indole
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概要
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The compound related to mitomycin B, 2,3-dihydro-7-hydroxy-6,9-dimethyl-5,8-dioxo-1H-pyrrolo [1,2-α] indole (III), was synthesized starting from 2,3,9,9a-tetrahydro-6,9-dimethyl-7-nitro-1H-pyrrolo [1,2-α] indole (II) via 2,3-dihydro-6,9-dimethyl-7-nitro-1H-pyrrolo [1,2-α] indole (X), 7-amino-2,3-dihydro-6,9-dimethyl-1H-pyrrolo [1,2-α] indole (XI), and 2,3-dihydro-6,9-dimethyl-7,8-dioxo-1H-pyrrolo [1,2-α] indole (VII). Some considerations were made on the mechanism of the formation of the dimers, 2,3-dihydro-5-(2', 3', 9', 9a'-tetrahydro-6', 9'-dimethyl-1H-pyrrolo [1,2-α] indol-7'-imino)-6,9-dimethyl-7,8-dioxo-1H-pyrrolo [1,2-α] indole (VIII) and 2,3-dihydro-5-(2', 3'-dihydro-6', 9'-dimethyl-1H-pyrrolo [1,2-α] indol-7'-imino)-6,9-dimethyl-7,8-dioxo-1H-pyrrolo [1,2-α] indole (IX), obtained by the oxidation of 7-amino-2,3,9,9a-tetrahydro-6,9-dimethyl-1H-pyrrolo [1,2-α] indole (V) with Fremy's salt.
- 公益社団法人日本薬学会の論文
- 1972-08-25
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