Syntheses and Reactions of Chloro-2-isopropyl-5-isobutylpyrazines Syntheses of Deoxymutaaspergillic Acid and 2-Hydroxy-3-isobutyl-6-isopropylpyrazine 1-Oxide
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概要
- 論文の詳細を見る
DL-Valyl-lencyl anhydride (III) was converted to mono- and di-chloro-isopropyl-isobutylpyrazines by treatment with phosphoryl chloride. These mono-chloropyrazines (VII and VIII) were oxidized and the products were converted to 2-isobutyl-5-isopropylpyrazine 1- and 4-oxides (XIV and XV) via hydrazino compounds. On the other hand, starting from 2-chloro-3-isobutyl-6-isopropylpyrazine (VII), two fungal metabolites, deoxymutaaspergillic acid (I) and 2-hydroxy-3-isobutyl-6-isopropylpyrazine 1-oxide (II), were prepared.
- 公益社団法人日本薬学会の論文
- 1978-07-25
著者
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太田 明広
東京薬科大学
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太田 明廣
東京薬科大学薬学部
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太田 明廣
Tokyo College Of Pharmacy
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正野 佐和子
Tokyo College of Pharmacy
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秋田 安男
Tokyo College of Pharmacy
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渡辺 徳弘
Tokyo College of Pharmacy
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太田 明広
Tokyo College of Pharmacy
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渡辺 徳弘
東京薬科大学薬学部
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滝沢 佳奈枝
Tokyo College of Pharmacy
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栗原 真知子
Tokyo College of Pharmacy
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太田 明広
東京薬大 薬
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