Synthesis of dl-Neohydroxyaspergillic Acid

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概要

• 論文の詳細を見る

• dl-Neohydroxyaspergillic acid (I), the l-isomer of which has been isolated from Aspergillus flavus, was synthesized from DL-leucine anhydride. By treatment of 2-chloro-3,6-diisobutylpyrazine 4-oxide (II) with acetic anhydride, an acetoxyl group was introduced into the isobutyl group. Deoxygenation of the N-oxide group at the 4-position of a 2-hydroxypyrazine 1,4-dioxide derivative (XII), prepared by hydrolysis of a 2-chloro-pyrazine 1,4-dioxide derivative (XI), was achieved using titanium (III) chloride to afford I.

• 社団法人日本薬学会の論文
• 1979-06-25

著者

• 太田 明廣

  東京薬科大学薬学部

• 太田 明廣

  Tokyo College Of Pharmacy

• 秋田 安男

  Tokyo College of Pharmacy

• 泉田 明子

  Tokyo College of Pharmacy

• 鈴木 郁子

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 鈴木 郁子

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 太田 明広

  東京薬大 薬

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