Effects of Dimethylpyrazine Isomers on Reproductive and Accessory Reproductive Organs in Male Rats

概要

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The effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats were studied. Following the administration of 2,5-dimethylpyrazine (100 mg/kg, s.c.), the weight of prostate and seminal vesicles, as well as testosterone levels in plasma were significantly decreased. One isomer of dimethylpyrazine, 2,6-dimethylpyrazine (100 mg/kg, s.c.), affected only the seminal vesicles, while 2,3-dimethylpyrazine had no influence on accessory reproductive organs. Following administration of 100 mg/kg of 2,5-dimethylpyrazine, acid phosphatase activity in the prostate and fructose content in the seminal vesicles were also significantly decreased compared with tissues from vehicle-treated animals. Weight of the testes and acid phosphatase activity therein were not affected following the administration of 2,5-dimethylpyrazine, nor were numbers of spermatozoa in the epididymis. These results showed that 2,5-dimethylpyrazine induced decrease in prostate and seminal vesicle weight by inhibiting testosterone uptake and reducing plasma testosterone levels.
社団法人日本薬学会の論文
1993-02-15