First Total Synthesis of Astechrome : Novel Hydroxamic Acid with an Indole-Pyrazine Skeleton
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概要
- 論文の詳細を見る
Astechrome (1), isolated from Aspergillus terreus IFO 6123 and 8835,was synthesized. Indolylmagnesium bromide (4) was coupled with a chloromethylpyrazine (5) to give 2-chloro-5-methoxy-3-methyl-6-[7-(3-methyl-2-butenyl)indol-3-yl]methylpyrazine 1-oxide (6), which was converted to the Fe salt (9) of a hydroxamic acid derivative (8). Oxidation of 9 with Co(salen) afforded 1.
- 社団法人日本薬学会の論文
- 1994-02-15
著者
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太田 明廣
東京薬科大学薬学部
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太田 明廣
Tokyo College Of Pharmacy
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青柳 裕
東京薬科大学薬学部
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青柳 裕
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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景 瀕
Tokyo College of Pharmacy
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島田 厚子
Tokyo College of Pharmacy
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前田 敦
Tokyo College of Pharmacy
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新井 靖代
Tokyo College of Pharmacy
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後藤 美紀子
Tokyo College of Pharmacy
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Shimada A
Kobe Pharmaceutical University
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島田 厚子
Kobe Pharmaceutical University
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太田 明廣
Department Of Pharmacognosy Tokyo College Of Pharmacy
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Aoyagi Y
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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