Conversion of 2,5-Diphenyl- and 2,5-Dibenzyl-pyrazines to 2,5-Diketopiperazines

スポンサーリンク

概要

• 論文の詳細を見る

• The reactions of 2,5-diphenyl- (I) and 2,5-dibenzyl-pyrazine 1-oxides (II) with phosphoryl chloride and acetic anhydride were examined. 2,5-Dichloro-3,6-diphenyl- (XI) and 2,5-dichloro-3,6-dibenzyl-pyrazines (XIII) were converted to the corresponding 2,5-diketopiperazines, α-phenylglycine anhydride (XXV) and phenylalanine anhydride (XXVI), respectively. The stereochemistry of the products is discussed. However, attempts to convert 2,5-dichloro-3,6-dihydroxymethylpyrazine (XXXIV) to serine anhydride were unsuccessful.

• 社団法人日本薬学会の論文
• 1979-12-25

著者

• 太田 明廣

  東京薬科大学薬学部

• 太田 明廣

  Tokyo College Of Pharmacy

• 秋田 安男

  Tokyo College of Pharmacy

• 中根 由美子

  Tokyo College of Pharmacy

• 太田 明広

  東京薬大 薬

関連論文

• 金属化合物の関与を鍵反応とした生理活性天然物の合成
• Pyrazine骨格を有する天然物の合成
• ピラジン類の反応と合成
• STEREOSELECTIVE 1,4-DIPOLAR CYCLOADDITIONS OF 2-(METHYLTHIO)-3,6-DIHYDRO-3,5-DIMETHYL-6-OXO-1-SUBSTITUTED PYRIMIDINIUM-4-OLATES WITH ALKENES
• First Total Synthesis of Astechrome : Novel Hydroxamic Acid with an Indole-Pyrazine Skeleton
• Mutarotase Activity in Serum and Urine of Patients with Renal Disease
• 簡単な構造のアルキル-及びアリールピラチン類の生理・薬理活性について
• Effects of 2,5-Dimethylpyrazine on Plasma Testosterone and Polyamines-and Acid Phosphatase-Levels in the Rat Prostate
• Effects of Dimethylpyrazine Isomers on Reproductive and Accessory Reproductive Organs in Male Rats
• Cleavage of C-O Bonds of Iminoethers and Methyl Hydroxamates with Grignard Reagents and Butyllithium
• Reduction of β-Ketoalkyl 2-(1-Dimethylaminoethyl)phenyl Sulfoxides : Synthesis of (-)-Matsutakeol
• Cross-Coupling Reactions of Chloropyrazines with 1-Substituted Indoles
• Cross-Coupling Reaction of Chloropyrazines with Acetylenes
• Syntheses of Mutaaspergillic and dl-Hydroxyaspergillic Acids
• Conversion of 2,5-Diphenyl- and 2,5-Dibenzyl-pyrazines to 2,5-Diketopiperazines
• Photocyclization of Styrylpyrazines
• Syntheses and Reactions of Some 2,5-Disubstituted Pyrazine Monoxides
• Synthesis of Deoxyneo-β-hydroxyaspergillic Acid
• Synthesis of dl-Neohydroxyaspergillic Acid
• Reaction of Some Halogenated Aromatic N-Heterocycles with Hexamethylphosphoric Triamide
• 1,3-Dipolar Cycloadditions. LXXVI. Cycloadditions of Diazomethane to Substituted Butadienes
• Synthese von DL-Aspergillussaure und DL-Deoxyaspergillussaure
• 溝口歌子氏追想 その2
• Nitration of Mononitroquinolines
• あきらめの立場から(文部省科学研究費申請と配分の問題点)
• Chem.Pharm.Bull.25年
• Relationship between Carcinogenicity and Electronic Structure of Mononitroquinolines
• Direct Fractionation Procedure for Hydrogen Peroxide-Acetic Acid Oxidation Products from Aromatic Amines by Reversed-Phase Liquid Chromatography
• ホオノキの成分研究(第4報) 葉の成分その1
• ツバキ実搾油粕より得られるインドール誘導体について着生カビ成分との関係
• ピリジン, ピラチン同族体およびN-オキシド誘導体の順相および逆相液体クロマトグラフィーにおける保持挙動
• Syntheses and Reactions of Chloro-2-isopropyl-5-isobutylpyrazines Syntheses of Deoxymutaaspergillic Acid and 2-Hydroxy-3-isobutyl-6-isopropylpyrazine 1-Oxide
• Deoxygenation of Heterocyclic N-Oxides by Chromium (II) Chloride

もっと見る 閉じる

スポンサーリンク