Cross-Coupling Reactions of Chloropyrazines with 1-Substituted Indoles
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概要
- 論文の詳細を見る
Palladium-catalyzed coupling reactions of 2-chloro-3,6-dialkylpyrazines with 1-tosylindole gave 1-tosyl-3-(3,6-dialkylpyrazin-2-yl)indoles as the main product in each case. The subsequent hydrolysis of the products yielded the corresponding 3(3,6-dialkylpyrazin-2-yl)indoles under alkaline conditions. Coupling reactions of 2-chloro-3,6-dialkyl-pyrazines with 1-methyl- or 1-benzylindole occurred at the 2-position of the indoles, but 2-chloro-3,5-diphenylpyrazine (1e) failed to react with 1-methylindole.
- 社団法人日本薬学会の論文
- 1989-06-25
著者
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太田 明廣
東京薬科大学薬学部
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太田 明廣
Tokyo College Of Pharmacy
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秋田 安男
Tokyo College of Pharmacy
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板垣 洋子
Tokyo College of Pharmacy
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滝沢 小百合
Tokyo College of Pharmacy
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太田 明広
東京薬大 薬
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