Formic Acid Reduction. III. Barbituric Acid Derivatives. New 5-Methylation Reaction of Barbituric Acid Derivatives with Formate and Course of the Reaction
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It has been found that after heating with a reagent, given by 5HCO_2H・2N (C_2H_5)_3,several barbituric acid derivatives were methylated at the 5-position. The reaction was revealed to proceed through an intermediate, 5,5'-methylidynebis (barbituric acid), which had been previously known as the usual reaction product obtained by heating with formic acid. The reaction course was found to involve an interesting aspect that the reagent carries out a saturation of the carbon-carbon double bond at the 5-position followed by a reductive fission of the bond.
- 公益社団法人日本薬学会の論文
- 1969-04-25
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関連論文
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