高分子ゲルビーズの凍結と乾燥(セミナー「ストレスと生物の応答・適応 : その分子・細胞機構と応用」)

概要

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Freezing and drying behavior of polymer gels in a bead form, used as models of biological systems, has been studied as understanding of the behavior is of practical importance for a successful preservation of the systems. Attention was focused on the anomalous ice crystallization during rewarming observed with a dextran gel of a certain density of crosslink. Size of ice crystals formed or presence of glassy water in the frozen gel was found, as a result, to depend on the polymer network characterized especially by the crosslink density of the gels. Drying behavior is also influenced by the characteristics of the polymer network. In conclusion, water in polymer gels is obstructed in diffusion by the polymer network, and freezing and drying behavior in the gels becomes different from that in aqueous solutions. These results should be taken into consideration in the practice of biopreservation as most biological systems have an extensive polymer network.
2003-08-30