アスコルビン酸エステルの代謝 : (III)各種アスコルビン酸誘導体の生理効果

概要

論文の詳細を見る
The antiscorbutic activities of ascorbic acid derivatives, such as benzoyl, ethoxycarbonyl, and 6-monoester or 2,6-diester of C_4,C_8,C_<12> and C_<16> fatty acids were compared with that of L-ascorbic acid in guinea pigs of about 200g by the oral administration of 1.0mg ascorbic acid equivalent. It has been shown that ethoxycarbonyl derivatives was little effective and benzoyl derivative was effective in some degree, on the other hand, that fatty acid derivatives were considerably effective. Among them 6-monoesters have been shown to be more effective than 2,6-diesters. Especially, octanoyl and lauroyl drivatives were more effective than butyryl derivative in 6-monoesters. These results come to good coincidence with those of enzymatic hydrolysis. Though it can be inferred the above aspects, considering from the ability of the micelle formation between bile salt and these ascorbic acid derivatives, further investigations on the hydrolytic enzymatic system and the permeability of cell membrane would be expected.
日本ビタミン学会の論文
1968-02-25