アザロマイシン生産菌 Streptomyces hygroscopicus培養液に対する濾過条件の検討

概要

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Filtration conditions for the culture broth of Streptomyces hygroscopicus were investigated to obtain quick separation of mycelia. Results gave a much higher yield of azalomycin F.1. Filtrate viscosity, μ, was expressed by Andrade's equation as a function of temperature, T.μ=1.29×10^<-3l2.05×10^3/T>Filtration time by filter press at 27℃ was half of that at 12.5℃.2. Cationic surfactant was effective to form floc and to decrease supernatant viscosity and turbidity.3. By adjusting the pH of broth to the range 2.5 to 4.0,floc formation increased, while supernatant viscosity and turbidity decreased. As a result, the rate of broth filtration markedly increased.4. Azalomycin F in the culture broth was stable for one hour under the conditions at pH2〜6,30℃.The elution of azalomycin F from mycelia to filtrate decreased in acidic pH, but increased in alkaline pH.
社団法人日本生物工学会の論文
1976-01-25