骨のγ-カルボキシグルタミン酸含有タンパク質のラット骨並びに血清中含有量に及ぼすビタミンDの影響

概要

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Weanling rats were raised for 6 weeks on either a rachitogenic diet (rachitic group), vitamin D-deficient diet (D-deficient group) or standard laboratory chow (normal group). After 6 weeks, the rachitic and D-deficient groups were given 500_<IU> of vitamin D_3 24 hours before sacrifice. Serum and bone BGP (bone γ-carboxyglutamic acid containing protein) contents in those rats were determined by radioimmunoassay using anti-rat BGP serum. BGP levels of bone did not show any significant difference between three groups. However, serum BGP levels of the rachitic group was significantly lower than those of the D-deficient and normal groups. On the other hand, the administration of vitamin D_3 caused a significant increase in serum BGP levels of the D-deficient group, whereas bone BGP levels of the rachitic and D-deficient groups and serum BGP levels of the rachitic group were not influenced by vitamin D_3.
日本ビタミン学会の論文
1984-04-25