シロネズミ小腸粘膜におけるビタミンD作用に依存するカルシウム結合たんぱく質の所在

概要

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Rat intestinal mucosa was divided to the proximal and the distal parts, and the ^<45>Ca-binding of their supernatant fraction (38,000×g, 20min) was analyzed by Sephadex G-25 column equilibrated with ^<45>Ca, ^<1)> Three peaks (I, II, III) were observed in the elution profile of the 750mμ absorbancy accompanying through the column, and two ^<45>Ca peaks (IA, IB) were corresponding with peak I.^<2)> The protein corresponding to IA was observed in the distal part rather than the proximal and increased by vitamin D_3 administration. The protein corresponding to IB was almost equal amounts in both parts. The IB in distal part was not increased with D_3,and that in the proximal was increased. Vitamin D_3 would stimulate the biosynthesis of protein IA, and then stimulate the diffusional process of calcium absorption. Active transport will be stimulated with the secondary effect.^<3)>
日本ビタミン学会の論文
1969-06-25