内用液剤の安定性におよぼす水質の影響

概要

論文の詳細を見る
Much attention has been paid to various factors affecting the stability of active ingredient in the oral liquid preparations, but little consideration has been given to the matter of the quality of water used in dispensing or compounding in hospital pharmacy. City water contains approximately 1.0 ppm of chlorine for disinfection. To clarify the effect of chlorineon drug stability, certain amount of chlorine was added successively to city water to maintain its concentration at 1.0 ppm. This water is nominated as "the Water" in this report. The following results were obtained: 1) 42 preparations out of 51 remained stable either in the Water or distilled water. 2) 6 preparations decreased the content of their ingredients when stored at room temperature, but they maintained the content for 7 to 10 days when preserved in a dark, cool place. These findings were obtained both in the Water and distilled water. 3) 2 preparations were in activated more when prepared with the Water than when prepared with distilled water. The loss of content was not significant within 7 days, but the Water should be avoided to maintain the contents of these medicines for along time. 4) 1 preparation showed little loss of content when prepared with distilled water, but showed about 80% loss when prerared with the Water, suggesting that such product should not be prepared with city water.
日本医療薬学会の論文
1985-10-20