血中テオフィリン動態の解析

概要

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Pharmacokinetics of theophylline was studied on 22 asthmatic patients. Aminophylline was administered in dose of 3.6-6.6 mg/kg by a single intravenous injection and by a constantrate intravenous infusion for 2 hours. Plasma theophylline concentrations were determined by high-pressure liquid chromatography. In case of single intravenous injection, plasma concentration reached the highest level of 12.7±3.31μg/ml immediately after the injection and, in case of a continuous intravenous infusion, plasma concentration reached the highest level of 9.1±1.60μg/ml at the end of the infusion. The serial plasma concentration data were analyzed by assuming the 1-and2-compartment model. In case of a single intravenous injection, the mean plasma theophylline clearance was 0.0517±0.01861 1/kg/hr with k_<10> 0.047±0.076 hr<-1>, α 6.689±4.313 hr<-1>, β 0.104±O.036 hr<-1>, and V O.389±0.128 1/kg ; in case of a continuous intravenous infusion, they were K_0/VK (1-e-<KT>) 8.91±1.46μg/ml, K O.120±O.0624 hr<-1>, V O.437±O.062 1/kg. These data should be useful in determining precise dosage requirements for theophlline therapy of asthma.
日本医療薬学会の論文
1979-05-20