薬物の蛋白結合測定への新しい微量限外ろ過器の評価

概要

論文の詳細を見る
For an attempt to evaluate the usefulness of newly developed microultrafiltration devices (Ultrafree C3LGC, Molcut IILGC, Minicent-30, Minicent-10 and Airpress-30), free fractions (FF) of phenytoin, carbamazepine, valproic acid, and disopyramide separated by these devices were compared with those obtained by a commercially available devices, MPS-1. The present study clearly showed that the correct FF of a drug could not be obtained by using an ultrafiltration device. The protein leakage through the membrane and the adsorption to the instruments may result in their differences between the FFs. The adsorption degree of these drugs seems to depend on their hydrophilicity, since the adsorption had a tendency to increase with the hydrophilic properties of the drugs. From these findings, it is recommended that a new device should be chosen by considering factors such as hydrophilicity of drugs and protein leakage through the membrane.
1988-12-20