Helicobacter pylori 除菌療法のラベプラゾールナトリウムと抗生剤2剤の2週間投与による消化性潰瘍の治癒効果

概要

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Triple therapy (proton pump inhibitor+amoxicilln+clarithromycin) for one week is considered to be the common eradication therapy for Helicobacter pylori (H. pylori) infection. The H. pylori eradication rate has been reported to be 87.5% after the administration of sodium rabeprazole, which is a proton pump inhibitor, along with two antibiotic drugs for one week [H. Miwa et al, Aliment. Pharmacol. Ther., 13, 741-746(1999)] .We performed a retrospective study to evaluate the treatment of 42 patients with H. pylori infection by the administration of sodium rabeprazole with two antibiotic drugs for a twoweek period. As a result, the H. pylori eradication rate was 93% (39 of 42 patients). A successful healing of the peptic ulcer with H. pylori was observed in all 39 patients. Side effects such as mild diarrhea appeared in only one patient. The triple therapy with sodium rabeprazole, amoxycillin, and clarithromycin for two weeks was therefore found to be sufficiently effective in healing peptic ulcers with an H. pylori infection.
日本医療薬学会の論文
2003-10-10