薬物の不定間隔, 不定用量投与時におけるパーソナルコンピューターによる薬物速度論解析とその応用(薬剤学)

概要

論文の詳細を見る
Patients hardly take drug(s) at equal doses and dosing intervals because medicines are usually taken in accordance with each meal. Pharmacokinetic analysis and plasma level simulations of drugs under conditions such as unequal doses and dosing intervals are important to examine clinically the effect and/or adverse effect during drug therapy. We developed a personal computer program, which was written in BASIC language, to calculate pharmacokinetic parameters with unequal doses and dosing intervals. Moreover, we propose new pharmacokinetic parameters which are the sum of periods lower than minimum effective concentration and higher than minimum toxic concentration within a definite period of plasma drug level simulation. These new parameters may be useful to evaluate the individual minimum effective (or toxic) concentration, therapeutic effect, and adverse effect of drugs, if we can get a correlation between these parameters and therapeutic drug effect or adverse effect.
公益社団法人日本薬学会の論文
1986-11-25