錠剤の硬度および崩壊度の吸湿による経日変化

概要

論文の詳細を見る
Effect of humidity on hardness and disintegration time was examined on 25 kinds of uncoated tablets. Depending on the humidity in storage, hardness of the tablets changed in the following three patterns : (1) Larger in relative humidity (RH) of 30-50% than in drier state, but smaller in RH more than 75%. (2) No marked change in dry state and in RH up to 30-50%, but smaller in RH more than 75%. (3) Largest in dry state, and smaller as humidity increases. Tablets were prevented from being moistened in low humidity, but not in high humidity. The effect of humidity on disintegration which occurred within one minute was not noted, since the disintegration time was too short. The disintegration time was reduced in 1 of 5 kinds of tablets which disintegrated in 1-2min, 1 of 4 in 2-3min, all of 4 in 3-5min, and 1 of 2 in 9-11 min.
日本医療薬学会の論文
1977-02-20