含弗素有機化合物の合成研究(第4報) : 弗素置換アミノプロピルベンツヒドリルエーテル系化合物の合成および薬理学的研究

概要

論文の詳細を見る
Six kinds of p-monohalogenated benzhydryl aminopropyl ether, which is represented by the general chemical formula, [chemical formula] (X=F, Cl; Y=piperidino, morpholino and 1-pyrrolodinyl), were synthesized. When compounds of both [chemical formula] reported in a previous paper were compared, LD_<50> of C_3 compounds is much greater than that of C_2 compounds, then the toxicity of C_3 compounds was found to be decreased remarkably. According to the Dews method [Brit. J. Pharmacol., 8,46 (1953)]which counts total number of blocking irradiation in 10 min., using phototransistor over experimental cages, each of which contains 5 mice, an influence of both types of medicines upon the voluntary activity of animals was examined. Administration of 1 mg./kg. of methamphetamine increased the voluntary activity of mice as 1.5〜1.7 times as much after 1 hr. However, by the administration of Cl-C_2-morpholin, Cl-C_3-morpholin and F-C_3-morpholin in advance, the amount, 5 mg./kg., which do not show any voluntary activity, was observed to antagonize to methamphetamine. Especially, F-C_3-morpholin showed very strong and long-lasting effect and an efficacy of this compound as a tranquilyzer will be expected.
社団法人日本薬学会の論文
1967-09-25