EFFECTS OF METHYLMERCURIC CHLORIDE INTOXICATION ON THE INTRACELLULAR ACTIVITY OF LYSOSOMAL ENZYMES IN RAT LIVER AND BRAIN

概要

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The activity of the lysosomal enzymes of rat liver after a single intraperitoneal injection of methylmercuric chloride (5.0mg/kg) was enhanced in the nuclear fraction during early post-injection (2hr to 7 days), while it decreased in the mitochondrial fraction and increased in the lysosomal fraction during late post-injection (14 days). Rat brain activity, however, was reduced in the nuclear, mitochondrial and lysosomal fractions during late post-injection (14 days). A high accumulation of total mercury was observed in the liver during early post-injection (36 hr and 7 days) while similar accumulation in the brain occured during late post-injection (7 days and 14 days). Both the mercury burdens and the enzyme activities of the rat liver and brain returned to normal levels within 30 days.
日本トキシコロジー学会の論文
1979-08-15