光化学治療の骨組織への影響 : 抜歯窩治癒過程における光化学治療の影響

概要

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Photodynamic therapy (PDT) with a photosensitizing drug and laser irradiation is a treatment for malignant tumor. We investigated the effect of PDT histopathologically on the extraction socket healing of the rat and immunohistochemically with bromodeoxyuridine (BrdU). A photosensitizing drug, hematoporphyrin oligomers (HpO), was injected intraperitoneally to rat at a dose of 20 mg/kg. Three or 72 hours after HpO injection, the extraction sockets were irradiated with a Nd-YAG pumped dye laser (630 nm). Less bone formation was observed in specimens subjected to PDT at three hours after HpO injection. In contrast, at 72 hours after HpO injection bone formation in sections where PDT was carried out was similar to that in the control. These findings suggested that PDT at 72 hours after HpO injection did not affect bone formation in extraction wounds.
硬組織再生生物学会の論文