Clinico-pathological investigation of oral squamous cell carcinoma with neck dissection. Relationship between eosinophil, lymph node reaction and cervical lymph node metastasis.:Relationship between eoshlophil, lymph node reaction and cervical lymph node

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Blood eosinophils, eosinophils infiltration around the tumor and lymph node reaction were investigated relatively to cervical lymph node metastasis in 17 patients of oral squamous cell carcinoma treated by tumorectomy with neck dissection. The eosinophils infiltrated around the tumor in the biopsy specimen and peripheral blood eosinophil was counted. Lymph node reaction which included germinal center hyperplasia (GCH) and sinus histiocytosis (SH), was evaluated in the surgical specimen of the neck. The following results were obtained: 1. The cases with high grade eosinophil infiltration (>50 cells in high power field) showed significantly higher incidences of cervical lymph node metastasis than those with low grade.(P<0.05). 2. There was no correlation between the levels of blood eosinophil and eosinophil infiltration around the tumor. 3. No distinct relationship was observed between blood eosinophil level and cervical lymph node metastasis. 4. Cervical lymph node metastasis was observed in 4 out of 5 patients with low grade SH. Incidence of GCH has no significant correlation to the lymph node metastasis.
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