2nd International Symposium on Genotoxic and Carcinogenic Thresholds
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概要
- 論文の詳細を見る
- 2012-11-20
著者
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Masumura Kenichi
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Nohmi Takehiko
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Honma Masamitsu
Division Of Genetics And Mutagenesis National Institute Of Health Science
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Horibata Katsuyoshi
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Yamada Masami
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Fukushima Shoji
Japan Bioassay Res. Center Japan Industrial Safety And Health Assoc.
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YASUI Manabu
Division of Genetics and Mutagenesis, National Institute of Health Sciences
関連論文
- Spontaneous and Induced gpt and Spi^- Mutant Frequencies in gpt delta Transgenic Rodents
- Spontaneous Mutagenesis in Rodents : Spontaneous Gene Mutations Identified by Neutral Reporter Genes in gpt Delta Transgenic Mice and Rats
- An Approach to Estimate Radioadaptation from DSB Repair Efficiency
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- In Vivo Mutagenesis Caused by Diesel Exhaust in the Testis of gpt delta Transgenic Mice
- N-Methyl-N-nitrosourea Concentration-dependent, Rather than Total Intake-dependent, Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Significance of Cyclin D1 Overexpression in Transitional Cell Carcinomas of the Urinary Bladder and its Correlation with Histopathological Features
- Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet-cell differentiation from liver metastasis
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide-induced liver damage in rats
- Differences in Sensitivity of F344 Rats from Different Breeders to Phenobarbital Hepatocarcinogenicity
- Differences in susceptibility to N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis
- Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes
- Lack of changes in the levels of liver and kidney cytochrome P-450 isozymes in p53(+/-)knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
- Differences among Three Sister Strains of NON/Shi Mice in Sensitivity to Urinary Tract Carcinogenesis by N-Butyl-N-(4-hydroxybutyl)nitrosamine.
- Validation of a Simple In Vitro Comet Assay Method Using CHL Cells
- Enhanced proliferative response of hepatocytes to combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens
- Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid : Association with Elevated Ornithine Decarboxylase Activity and Formation of 8-Hydroxydeoxyguanosine in the Liver
- p53 and H-ras Mutations and Microsatellite Instability in Renal Pelvic Carcinomas of NON/Shi Mice Treated with N-Butyl-N-(4-hydroxybutyl)-nitrosamine: Different Genetic Alteration from Urinary Bladder Carcinoma
- Inhibitory Effects of S-Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis
- p53 in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry
- Cyclin D1 Overexpression in Rat Two-Stage Bladder Carcinogenesis and its Relationship with Oncogenes, Tumor Suppressor Genesand Cell Proliferation
- Inhibition of Development of N,N'-Dimethylhydrazine-induced Rat Colonic Aberrant Crypt Foci by Pre, Post and Simultaneous Treatments with 24R ,25-Dihydroxyvitamin D_3
- Susceptibility of Four F_1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis
- Mutation Induction in Cultured Human Cells after Low-dose and Low-dose-rate γ-ray Irradiation : Detection by LOH Analysis
- Sensitive Detection of LOH Events in a Human Cell Line after C-ion Beam Exposure
- Effect of a p53 codon 237 mutation on X-ray induced HPRT mutations
- Mutation induction after low-dose carbon-ion beam irradiation of frozen human cultured cells
- Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats
- P081 Chemopreventive effects of Tamarind (Tamarindus indica L) husk extract on the early stages of rat hepatocarcinogenesis
- O-04 Chemopreventive effects of Tamarind (Tamarindus indica L) husk extract on the early stages of rat hepatocarcinogenesis(ACEM Oral Presentation I)
- A fate of DNA double strand breaks in mammalian cells
- Oral Carcinogenicity and Toxicity of 2-Amino-4-chlorophenol in Rats
- Design and performance of a system for blood collection of rats under whole-body inhalation exposure
- Identification of an N-acetylcysteine conjugate in the urine after oral administration of 2,4-dichloro-1-nitrobenzene to rats
- Thirteen-week oral toxicity of 1,4-dioxane in rats and mice
- Thirteen-week Inhalation Toxicity of Carbon Tetrachloride in Rats and Mice
- Existence of a Threshold for the Genotoxic Carcinogens : Evidence from Mechanism-based Carcinogenicity Studies
- Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident
- Hormesis in Carcinogenicity of Non-genotoxic Carcinogens
- Aberrant expression of E-cadherin and β-catenin in association with transforming growth factor-β1 in urinary bladder lesions in humans after the Chernobyl accident
- Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N-butyl-N-(4-hydroxybutyl)-nitrosamine
- Influence of Strain and Diet on Hepatocarcinogenicity of N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) in Rats : Slight Inhibition of Preneoplastic Liver Lesion Development by Uracil
- Esophageal tuberculosis presenting with an appearance similar to that of carcinoma of the esophagus
- Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice
- Efficiency of Rebamipide in the Prevention of Remnant Gastritis after Distal Gastrectomy
- Application of Genetically Engineered Bacteria Carrying Human Cytochrome P450 to Toxicological Studies
- Carcinogenicity of Methylurea or Morpholine in Combination with Sodium Nitrite in a Rat Multi-organ Carcinogenesis Bioassay
- Lack of Promoting Effects of α-Linolenic, Linoleic or Palmitic Acid on Urinary Bladder Carcinogenesis in Rats
- Self-Expandable Metallic Stent for Unresectable Malignant Strictures in the Esophagus and Cardia
- DOSE-RELATED INCREASES IN QUANTITATIVE VALUES FOR GLUTATHIONE S-TRANSFERASE PLACENTAL FORM (GST-P) POSITIVE FOCI AND CYTOCHROME P-450 LEVELS IN THE LIVER OF F344 RATS EXPOSED TO PHENOBARBITAL SODIUM (PB) IN A MEDIUM-TERM BIOASSAY
- Strain Differences in Sensitivity to the Promoting Effect of Sodium L-Ascorbate in a Two-stage Rat Urinary Bladder Carcinogenesis Model
- Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis
- Ambulatory intraesophageal bilirubin monitoring in Japanese patients with gastroesophageal reflux
- INHIBITING EFFECTS OF DIETHYLMALEATE OR NH_4Cl ON NaHCO_3, BUT NOT BUTYLATED HYDROXYANISOLE, PROMOTION OF URINARY BLADDER CARCINOGENESIS IN MALE F344 RATS INITIATED WITH N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE
- Lack of Enhanced Epithelial Cell Proliferation in the Urinary Bladder of Heterozygous p53 Knockout Mice Given Sodium Ortho-phenylphenate or Uracil
- Are tobacco use and urine pH indicated as risk factors for bladder carcinoma?
- Overexpression of Cyclin D1 in Rat Esophageal Carcinogenesis Model
- Low susceptibility of nude mice to induction of invasive urinary bladder cancers by N-Ethyl-N-(4-hydroxybutyl) nitrosamine (EHBN).
- Chemopreventive Effects of Nobiletin against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta Transgenic Mice
- Development of Tester Strains Deficient in Nth/Nei DNA Glycosylases to Selectively Detect the Mutagenicity of Oxidized DNA Pyrimidines
- Development of a Bacterial Hyper-sensitive Tester Strain for Specific Detection of the Genotoxicity of Polycyclic Aromatic Hydrocarbons
- Thoracoscopic Esophagectomy for Intrathoracic Esophageal Cancer
- Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment
- Expression and Localization of Ornithine Decarboxylase in Reversible Papillomatosis Induced by Uracil in Rat Bladder
- S-Methylcysteine and Cysteine Are Inhibitors of Induction of Glutathione S-Transferase Placental Form-positive Foci during Initiation and Promotion Phases of Rat Hepatocarcinogenesis
- International Symposium on Genotoxic and Carcinogenic Thresholds
- A11 MODIFYING EFFECTS OF BERAPROST SODIUM ON N-METHYL-N-NITROSOUREA CARCINOGENESIS IN F344 RATS
- Mutation Spectra in Cisplatin- and Transplatin-treated GDL1 Cells Clarified the Different Mode of Action of These Compounds in Mammalian Cells
- 223 Modifying Effects of Hepatocarcinogens or Antioxidants on Preneoplastic and Neoplastic Lesion Development in a Multi-organ Carcinogenesis Bioassay Using F344 Rats.
- Microcystin-LR is not Mutagenic in vivo in the λ/lacZ Transgenic Mouse (Muta^ Mouse)
- The different sensibility to 5-fluorouracil in three cell lines, mouse lymphoma L5178Ytk^ cells, human lymphoblastoid TK6 and WTK-1 cells. (MUTAGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Mutagenicity Tests Using Cultured Human Cells : Application of Gene Mutation Assay in Thymidine Kinase (tk) Gene of A Human Lymphoid Cell Line (Tk6)
- Fullerene (C_) Is Negative in the In Vivo Pig-A Gene Mutation Assay
- Two- and 13-week Inhalation Toxicities of Indium-tin Oxide and Indium Oxide in Rats
- Inhalation Carcinogenicity and Chronic Toxicity of Indium-tin Oxide in Rats and Mice
- Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
- Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
- EFFECTS OF 7, 8-BENZOFLAVONE AND SKF 525-A ON THE ENZYME-MEDIATED MUTAGENICITY OF PHENYLENEDIAMINES
- DIFFERENTIAL MUTAGENICITIES OF TRIAMINO BENZENES AGAINST SALMONELLA TYPHIMURIUM TA 98 IN THE PRESENCE OF S9 FRACTIONS FROM POLYCHLORINATED BIPHENYLS-, PHENOBARBITAL- OR 3-METHYLCHOLANTHRENE-PRETREATED RATS, HAMSTERS AND MICE
- Genotoxicity of microcystin-LR in vitro and in vivo
- Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats : Evidence for the existence of no-effect levels and a mechanism involving p21^
- Possible Mechanisms of Practical Thresholds for Genotoxicity
- P-102 The Mouse Lymphoma Assay detects recombination, deletion, and aneuploidy(Poster Session)
- GENOMIC INSTABILITY IN P53 AND MISMATCH REPAIR MUTANT HUMAN LYMPHOBLASTOID CELLS.
- Evaluation of In Vivo Mutagenicity by 2,4-Diaminotoluene and 2,6-Diaminotoluene in Liver of F344 gpt delta Transgenic Rat Dosed for 28 Days : A Collaborative Study of the gpt delta Transgenic Rat Mutation Assay
- Evaluation of the in vivo Mutagenicity of Nickel Subsulfide in the Lung of F344 gpt delta Transgenic Rats Exposed by Intratracheal Instillation : A Collaborative Study for the gpt delta Transgenic Rat Mutation Assay
- Embryonic Lethality in Mice Lacking Mismatch-Specific Thymine DNA Glycosylase Is Partially Prevented by DOPS, a Precursor of Noradrenaline
- Evaluation of the Genotoxicity of Aristolochic Acid in the Kidney and Liver of F344 gpt delta Transgenic Rat Using a 28-Day Repeated-dose Protocol : A Collaborative Study of the gpt delta Transgenic Rat Mutation Assay
- Modulatory Effects of Capsaicin on N-diethylnitrosamine (DEN)-induced Mutagenesis in Salmonella typhimurium YG7108 and DEN-induced Hepatocarcinogenesis in gpt Delta Transgenic Rats
- Threshold for Genotoxic Carcinogens : The Central Concern in Carcinogenic Risk Assessment
- 2nd International Symposium on Genotoxic and Carcinogenic Thresholds
- in vivo Approaches to Identify Mutations and in vitro Research to Reveal Underlying Mechanisms of Genotoxic Thresholds
- Molecular mechanisms underlying ochratoxin A-induced genotoxicity : global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression
- Expression and Activity of Human DNA Polymerase η in Escherichia coli