DIFFERENTIAL MUTAGENICITIES OF TRIAMINO BENZENES AGAINST SALMONELLA TYPHIMURIUM TA 98 IN THE PRESENCE OF S9 FRACTIONS FROM POLYCHLORINATED BIPHENYLS-, PHENOBARBITAL- OR 3-METHYLCHOLANTHRENE-PRETREATED RATS, HAMSTERS AND MICE
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概要
- 論文の詳細を見る
Mutagenicity of 6 aminobenzene derivatives against Salmonella typhimurium TA 98 was studied in the presence of various S9 fractions. S9, which has been prepared form the livers of rats, hamsters and mice after pretreatment with different types of inducers ; polychlorinated biphenyls, phenobarbital and 3-methylcholanthrene, was used as the methabolic activating enzyme in this mutation assay. The S9 fractions from 3-methylcholanthrene-treated rats and mice are most useful for mutation induction by the all aminobenzenes used. The mutagenic activity of the compounds was clearly correlated to 3-methylcholanthrene-induced cytochrome P-450. However, any significant correlation between aniline hydroxylase activity and the mutagenesis was not observed.
- 日本トキシコロジー学会の論文
- 1979-11-15
著者
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Yoshikawa Kunie
Division Of Mutagenesis Biological Safety Research Center National Institute Of Hygienic Sciences
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Nohmi Takehiko
Division Of Genetics And Mutagenesis National Institute Of Health Sciences
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Nohmi Takehiko
Division Of Mutagenesis Biological Safety Research Center National Institute Of Hygienic Sciences
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Ishidate Motoi
Division Of Mutagenesis Biological Safety Research Center National Institute Of Hygienic Sciences
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HARADA Ryucihirou
Division of Mutagenesis, National Institute of Hygienic Sciences
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INOKAWA Yoshiyuki
Division of Mutagenesis, National Institute of Hygienic Sciences
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Harada Ryucihirou
Division Of Mutagenesis National Institute Of Hygienic Sciences
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Inokawa Yoshiyuki
Division Of Mutagenesis National Institute Of Hygienic Sciences
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