Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model
スポンサーリンク
概要
- 論文の詳細を見る
We have reported the antiallergic activities of the immunostimulatory oligodeoxynucleotide (ODN) BL07S, identified from genomic DNA of Bifidobacterium longum BB536 from in vitro and in vivo studies. The present study evaluated the efficiency of ODN BL07S in preventing allergic responses by oral administration. Oral administration of BL07S suppressed serum ovalbumin (OVA)-specific immunoglobulin (Ig) E levels and improved the OVA-specific IgG2a/IgG1 ratio. ODN BL07S increased Th1 cytokine and decreased Th2 cytokine production in splenocytes. These results suggest that immunostimulatory ODNs are potentially associated with the antiallergic effects of probiotics.
- 社団法人 日本農芸化学会の論文
- 2006-08-23
著者
-
Xiao Jin-zhong
Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd.
-
IWATSUKI Keiji
Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd.
-
Iwatsuki Keiji
Food Sci. & Technol. Inst. Morinaga Milk Ind. Co. Ltd.
-
Iwatsuki Keiji
Food Science And Technology Institute Morinaga Milk Industry Co. Ltd.
-
IWABUCHI Noriyuki
Food Science and Technology Institute, Morinaga Milk Industry Co., Ltd.
-
TAKAHASHI Noritoshi
Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
-
MIYAJI Kazuhiro
Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
-
KITAZAWA Haruki
Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
-
SAITO Tadao
Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University
-
Iwatsuki Keiji
Food Sci. And Technol. Inst. Morinaga Milk Ind. Co. Ltd.
-
Kitazawa Haruki
Laboratory Of Animal Products Chemistry Graduate School Of Agricultural Science Tohoku University
-
Xiao Jin-zhong
Food Science And Technology Institute Morinaga Milk Industry Co. Ltd.
-
Miyaji Kazuhiro
Food Research And Development Laboratory Morinaga Milk Industry Co. Ltd.
-
Takahashi Noritoshi
Food Research And Development Laboratory Morinaga Milk Industry Co. Ltd.
-
Saito Tadao
Laboratory Of Animal Products Chemistry Graduate School Of Agricultural Science Tohoku University
-
XIAO Jin-zhong
Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
-
IWATSUKI Keiji
Food Research and Development Laboratory, Morinaga Milk Industry Co., Ltd.
関連論文
- Effect of Enumeration Method on Bifidobacterium Cell Counts in Commercial Powder Products
- Antibiotic Susceptibility of Bifidobacterial Strains Distributed in the Japanese Market
- Suppressive Effects of Bifidobacterium breve Strain M-16V on T-Helper Type 2 Immune Responses in a Murine Model(Miscellaneous)
- Safety Evaluation of Two Probiotic Bifidobacterial Strains, Bifidobacterium breve M-16V and Bifidobacterium infantis M-63, by Oral Toxicity Tests Using Rats
- cDNA Subtractive Cloning of Genes Expressed during Early Stage of Appressorium Formation by Magnaporthe grisea
- An Anti-hydrotactic Response and Solid Surface Recognition of Germ Tubes of the Rice Blast Fungus, Magnaporthe grisea
- Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity
- In Vitro Th1 Cytokine-Independent Th2 Suppressive Effects of Bifidobacteria
- Clinical Efficacy of Probiotic Bifidobacterium longum for the Treatment of Symptoms of Japanese Cedar Pollen Allergy in Subjects Evaluated in an Environmental Exposure Unit
- Oral Administration of an Immunostimulatory DNA Sequence from Bifidobacterium longum Improves Th1/Th2 Balance in a Murine Model
- Effect of Partially Hydrolyzed Guar Gum (PHGG) on the Bioaccessibility of Fat and Cholesterol
- Suppressive Effects of Dietary Fiber in Yogurt on the Postprandial Serum Lipid Levels in Healthy Adult Male Volunteers
- Recombinant Human Intelectin Binds Bovine Lactoferrin and Its Peptides(Biochemistry)
- Characterization of Flavor Compounds Released During Grinding of Roasted Robusta Coffee Beans
- Bacteriocin production of probiotic Lactobacillus gasseri LA39 isolated from human feces in milk-based media
- Lactic Acid Bacteria (LAB) Bind to Human B- or H-Antigens Expressed on Intestinal Mucosa
- Swine Intestinal Immunity via Toll-like Receptors and Its Advanced Application to Food Immunology
- Study on Probiotic Lactic Acid Bacteria and Their Applications to New Functional Foods
- Identification of Five Phospho-β-glycosidases from Lactobacillus gasseri ATCC33323T Cultured in Lactose Medium
- A New Assay Using Surface Plasmon Resonance (SPR) to Determine Binding of the Lactobacillus acidophilus Group to Human Colonic Mucin
- Heterologous expression of gassericin A, a bacteriocin produced by Lactobacillus gasseri LA39
- Safety Evaluation of Two Probiotic Bifidobacterial Strains, Bifidobacterium breve M-16V and Bifidobacterium infantis M-63, by Oral Toxicity Tests Using Rats
- Effects of Ropy Sour Milk on the Metastasis of Lewis Lung Carcinoma in Mice (Food & Nutrition)
- Molecular Cloning and Sequencing of Two Phospho-β-galactosidase I and II Genes of Lactobacillus gasseri JCM1031 Isolated from Human Intestine
- A New Screening Method for the Selection of Lactobacillus acidophilus Group Lactic Acid Bacteria with High Adhesion to Human Colonic Mucosa
- Sequence Analysis by Cloning of the Structural Gene of Gassericin A, a Hydrophobic Bacteriocin Produced by Lactobacillus gasseri LA39
- Coexistence of Two Kinds of 6-Phospho-β-Galactosidase in the Cytosol of Lactobacillus gasseri JCM1031
- Purification and Characterization of 6-Phospho-β-galactosidase from Lactobacillus gasseri JCM 1031
- Primary Amino Acid and DNA Sequences of Gassericin T, a Lactacin F-Family Bacteriocin Produced by Lactobacillus gasseri SBT2055
- Gassericin A ; an Uncommon Cyclic Bacteriocin Produced by Lactobacillus gasseri LA39 Linked at N-and C-Terminal Ends
- Application of Two-dimensional Mapping for an Analysis of Galactosyllactoses in Yogurt
- Rapid Detection Method for Bacteriocin and Distribution of Bacteriocin-producing Strains in Lactobacillus acidophilus Group Lactic Acid Bacteria Isolated from Human Feces
- Isolation of a New Minor Protein (Ovofactor-1), Which Has a Cell Growth Promoting Activity, from Hen's Egg White by Heparin Affinity Chromatography
- Isolation and Characterization of a Highly Hydrophobic New Bacteriocin (Gassericin A) from Lactobacillus gasseri LA39
- Identification of Five Phospho-β-glycosidases from Lactobacillus gasseri ATCC33323^T Cultured in Lactose Medium
- Effects of Orally Administered Bovine Lactoperoxidase on Dextran Sulfate Sodium-Induced Colitis in Mice
- Antiobesity Effects of Bifidobacterium breve Strain B-3 Supplementation in a Mouse Model with High-Fat Diet-Induced Obesity
- Specific Adsorption of Immunoglobulin G_1 in Bovine Colostrum on Sephadex and Its Mitogenic Activity on Mouse Splenocytes(Food & Nutrition)
- Microbiota analysis of Caspian Sea yogurt, a ropy fermented milk circulated in Japan
- Oral Administration of Bifidobacterium longum Ameliorates Influenza Virus Infection in Mice
- Effect of Enumeration Method on Bifidobacterium Cell Counts in Commercial Powder Products
- Antibiotic Susceptibility of Bifidobacterial Strains Distributed in the Japanese Market
- Hemagglutination Activity of Lactobacillus acidophilus Group Lactic Acid Bacteria
- Immunostimulatory Activities of Lactic Acid Bacteria via Toll-like Receptors
- New Minor Glycoproteins Isolated from Hen's Egg White by Heparin-affinity Chromatography
- Metabolomics-based component profiling of hard and semi-hard natural cheeses with gas chromatography/time-of-flight-mass spectrometry, and its application to sensory predictive modeling(BREWING AND FOOD TECHNOLOGY)
- Antibacterial Activity of the Lactoperoxidase System Combined with Edible Laminaria Hot-Water Extract as a Source of Halide Ions
- Metabolomics-based component profiling of hard and semi-hard natural cheeses with gas chromatography/time-of-flight-mass spectrometry, and its application to sensory predictive modeling
- Metabolic fingerprinting of hard and semi-hard natural cheeses using gas chromatography with flame ionization detector for practical sensory prediction modeling(BREWING AND FOOD TECHNOLOGY)
- An Adhesin-Like Protein, Lam29, from Lactobacillus mucosae ME-340 Binds to Histone H3 and Blood Group Antigens in Human Colonic Mucus