STUDIES ON ANTIVIRAL ANTIBIOTICS PRODUCED BY STREPTOMYCES:IV. SCREENING OF ANTIBIOTICS AGAINST INFLUENZA VIRUS IN VITRO

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概要

• 論文の詳細を見る

• Four hundred and eighteen culture filtrates of the freshly isolated streptomyces were examined on the activity against influenza virus cultivated in vitro, in which a piece of chorioallantoic membrane of embryonated egg was suspended in Hanks′ solution. The results indicated that 21.5% of the tested filtrates were active. Further, the active filtrates were studied in regard to some of the biological and physicochemical properties such as effect on dehydrogenase activity of the tissue, toxicity for mice, other antimicrobial activities, taxonomic characteristics and solubility of the active agent in the organic solvent. A definite relationship between the antiviral activity and other biological properties could not be established in the present experiment. Eleven active filtrates were selected for isolation of active principles in the respect that they possessed all unique biological properties.The usage of the in vitro screening of antiviral agents was discussed.

• 財団法人 学会誌刊行センターの論文

著者

• Ishihara Kyoko

  Department Of Internal Medicine Matsubara Municipal Hospital

• Anzai Atsushi

  Department Of Applied Chemistry Graduate School Of Engineering Hiroshima University

• Kobayashi Nobuo

  Deparment Of Physics Faculty Of Science Tokyo Metropolitan University

• HINUMA YORIO

  Department of Bacteriology, School of Medicine, Tohoku University

• ANZAI ATSUSHI

  Department of Bacteriology, School of Medicine, Tohoku University

• KUROYA MASAHIKO

  Department of Bacteriology, School of Medicine, Tohoku University

• HIGO NAOKI

  Department of Bacteriology, School of Medicine, Tohoku University

• KIKUCHI KO

  Department of Bacteriology, School of Medicine, Tohoku University

• KANEKO TAMOTSU

  Department of Bacteriology, School of Medicine, Tohoku University

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