Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs
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概要
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The aim of this study was to investigate the effect of tunnel structured β-tricalcium phosphate (β-TCP) on the regenerative potential of basic fibroblast growth factor-2 (bFGF-2) in class III furcation defects in dogs. The furcations of 30 mandibular premolar teeth received: 1) 0.3% bFGF-2 solution in conjunction with β-TCP; 2) 0.3% bFGF-2 solution; and 3) no implant material (Control group). The dogs were sacrificed 8 weeks post-surgery, and healing was evaluated histologically. New bone formation was significantly greater in the bFGF-2/β-TCP group compared to the bFGF-2 solution and Control groups (p<0.01). New cementum formation in the bFGF-2/β-TCP and bFGF-2 solution groups was significantly greater than that in the Control group (p<0.01). These findings suggested that bFGF-2 alone enhances connective tissue attachment in a manner similar to the combination of bFGF-2 and β-TCP. Furthermore, this combination enhances bone formation up to the fornix in class III furcation defects.
著者
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Kuboki Yoshinori
Hokkaido Univ.
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Saito Emiko
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Ohata Noboru
Department Of Oral Functional Science Graduate School Of Dental Medicine Hokkaido University
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Kato Tsuyoshi
Department Of Chemistry Graduate School Of Science Tohoku University
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Kimura Mariko
Pilot Corporation
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Kuboki Yoshinori
Hokkaido University Graduate School Of Dental Medicine
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Takahashi Tomomi
Support Section For Education And Research Division Of Oral Health Science Hokkaido University Graduate School Of Dental Medicine
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Honma Yoshiyuki
Support Section For Education And Research Division Of Oral Health Science Hokkaido University Graduate School Of Dental Medicine
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Nakajima Toshinori
Department of Electrical Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa 992-8510, Japan
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Saito Akira
Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
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YUGE Fumihiko
Department of Oral Rehabilitation, Division of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine
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OHATA Noboru
Department of Oral Rehabilitation, Division of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine
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NAKAJIMA Toshinori
Department of Oral Rehabilitation, Division of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine
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SAITO Akira
Department of Oral Rehabilitation, Division of Oral Functional Science, Hokkaido University Graduate School of Dental Medicine
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