A Case of Hypouricemia due to Combined Reabsorption Defect
スポンサーリンク
概要
- 論文の詳細を見る
Hypouricemia in a 41-year-old male is reported. His serum urate was 0.4-0.8 mg/dl Through laboratory studies and roentgenology, known causes other than renal tubular dysfunction were ruled out as a mechanism of his hypouricemia. Detailed clearance study was performed to clarify his urate homeostasis. His fractional excretion of urate (ratio of urate to creatinine clearance), exceeding 100% in the basal state, slightly increased to 114% by benzbromarone and decreased to 99% by the serial administration of pyrazinamide. This finding demonstrates that his hypouricemia was due to a combined type of renal urate reabsorption defect.<BR>We also reviewed 69 reported cases of renal hypouricemia and discussed the relevance of serum urate levels and types of tubular defects.
- Japanese Society of Gout and Nucleic Acid Metabolismの論文
著者
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花房 俊昭
大阪大学医学部第二内科
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中島 弘
大阪大学医学部分子制御内科学(第二内科)
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河野 典夫
大阪大学医学部保健学科
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野中 共平
大阪大学医学部第二内科
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森脇 要
大阪大学医学部内科学第二教室
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五味 正裕
大阪大学医学部第二内科
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嶺尾 郁夫
大阪大学医学部第二内科
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伊藤 秀彦
大阪大学医学部第二内科
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鷲見 誠一
大阪大学医学部第二内科
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垂井 清一郎
大阪大学医学部中央臨床検査部
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